Insider Trades - ORBIMED ADVISORS LLC

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ORBIMED ADVISORS LLC: Declared Holdings
Company/Relationship	Reported	Shares	Ownership
ARYx Therapeutics, Inc. Beneficial Owner (10% or more) NasdaqGM:ARYX (historical quotes, profile, other insiders)	22-May-09	1,340,139	Indirect
Athersys, Inc. Director NasdaqCM:ATHX (historical quotes, profile, other insiders)	7-Jan-10	1,805,100	Indirect
Biodel Inc. Director NasdaqGM:BIOD (historical quotes, profile, other insiders)	10-Jun-09	1,485,904	Indirect
NxStage Medical, Inc. Director NasdaqGM:NXTM (historical quotes, profile, other insiders)	26-Aug-08	5,718,256	Indirect

Insider & restricted shareholder transactions reported over the last two years
Date Shares Stock Transaction
7-Jan-10 *4,947 ATHX Disposition (Non Open Market) at $0 per share.
28-Dec-09 *1,800,153 ATHX Disposition (Non Open Market) at $0 per share.
10-Jun-09 *26,988 BIOD Sale at $5.24 per share.
(Proceeds of $141,417)
9-Jun-09 *300,000 BIOD Disposition (Non Open Market) at $0 per share.
22-May-09 *2,000,000 ARYX Sale at $4 per share.
(Proceeds of $8,000,000)
17-Mar-09 *110,000 ATHX Purchase at $0.84 per share.
(Cost of $92,400)
16-Mar-09 *52,200 ATHX Purchase at $0.65 per share.
(Cost of $33,930)
14-Nov-08 *1,214,646 ARYX Purchase
26-Aug-08 *27,700 NXTM Purchase at $3.50 per share.
(Cost of $96,950)
25-Aug-08 *108,900 NXTM Purchase at $3.37 per share.
(Cost of $366,993)
21-Aug-08 *26,100 NXTM Purchase at $3.25 per share.
(Cost of $84,825)
23-May-08 *5,555,556 NXTM Purchase at $4.50 per share.
(Cost of $25,000,002)
23-May-08 *5,555,556 NXTM Statement of Ownership
22-May-08 *268,000 ATHX Purchase at $2.40 per share.
(Cost of $643,200)
21-May-08 *130,000 ATHX Purchase at $2.40 per share.
(Cost of $312,000)
13-May-08 *50,000 ATHX Purchase at $2.40 per share.
(Cost of $120,000)
12-Feb-08 *154,000 BIOD Sale at $14.48 per share.
(Proceeds of $2,229,920)
* Indicates that some (or all) shares are held indirectly (e.g. in a trust, by a spouse, etc.)

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Insider & restricted shareholder transactions reported over the last two years
Date	Shares	Stock	Transaction
7-Jan-10	*4,947	ATHX	Disposition (Non Open Market) at $0 per share.
28-Dec-09	*1,800,153	ATHX	Disposition (Non Open Market) at $0 per share.
10-Jun-09	*26,988	BIOD	Sale at $5.24 per share. (Proceeds of $141,417)
9-Jun-09	*300,000	BIOD	Disposition (Non Open Market) at $0 per share.
22-May-09	*2,000,000	ARYX	Sale at $4 per share. (Proceeds of $8,000,000)
17-Mar-09	*110,000	ATHX	Purchase at $0.84 per share. (Cost of $92,400)
16-Mar-09	*52,200	ATHX	Purchase at $0.65 per share. (Cost of $33,930)
14-Nov-08	*1,214,646	ARYX	Purchase
26-Aug-08	*27,700	NXTM	Purchase at $3.50 per share. (Cost of $96,950)
25-Aug-08	*108,900	NXTM	Purchase at $3.37 per share. (Cost of $366,993)
21-Aug-08	*26,100	NXTM	Purchase at $3.25 per share. (Cost of $84,825)
23-May-08	*5,555,556	NXTM	Purchase at $4.50 per share. (Cost of $25,000,002)
23-May-08	*5,555,556	NXTM	Statement of Ownership
22-May-08	*268,000	ATHX	Purchase at $2.40 per share. (Cost of $643,200)
21-May-08	*130,000	ATHX	Purchase at $2.40 per share. (Cost of $312,000)
13-May-08	*50,000	ATHX	Purchase at $2.40 per share. (Cost of $120,000)
12-Feb-08	*154,000	BIOD	Sale at $14.48 per share. (Proceeds of $2,229,920)